Treatment of high alkaline phosphatase in pregnancy
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Alkaline phosphatase high 37 weeks pregnant...
Does an abnormally elevated maternal alkaline phosphatase pose problems for the fetus?
Abstract
We report a potential association between an abnormally raised pregnancy level of alkaline phosphatase (ALP) and intrauterine growth restriction (IUGR).
There are few reports of women with abnormally high ALP during pregnancy.
Normal range of alkaline phosphatase in pregnancy
However, there is work to suggest an association with placental insufficiency, low birth weight and preterm delivery. In conjunction with a rising ALP, fetal IUGR and intermittent absence of umbilical artery end diastolic flow had evolved.
A greatly elevated ALP may be a marker for placental insufficiency and IUGR.
Keywords: pregnancy, materno-fetal medicine
Background
The enzyme, alkaline phosphatase (ALP), is derived mostly from liver and bone but is also found in the intestine, kidney and placenta.1 An increase in ALP production occurs when tissues are functionally disturbed, for example, hepatic obstruction or greatly stimulated, for example, the placenta in pregnancy.
During pregnancy, levels may reach three times the upper limit of normal (30–130 IU
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