Lansoprazole side effects long-term

 US Pharm. 2017;42(7)4-7.

Since the introduction of the first proton pump inhibitor (PPI) in 1989, this class of medications has become a staple in the management of gastroesophageal reflux disease (GERD) and other acid-related disorders.

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PPIs are potent agents that significantly reduce acid secretion by irreversibly binding to H⁺/K⁺ adenosine triphosphatase, or the proton pump, located in the parietal cells. Overall, these medications have among the highest sales levels in the United States, approaching nearly $10 billion dollars in 2012.¹ 

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PPIs have proven to be very effective and safe in managing GERD, healing peptic ulcer disease, and reducing the incidence of nonsteroidal anti-inflammatory drug–associated gastropathy, becoming one of the most-prescribed medications by healthcare providers.

Their superb efficacy and low toxicity resulted in the approval of the first OTC product in 2003, providing patients with an option other than antacids and H2-receptor antagonists for self-medic

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